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Idling by DNA polymerase δ maintains a ligatable nick during lagging-strand DNA replication
During each yeast cell cycle, ∼100,000 nicks are generated during lagging-strand DNA replication. Efficient nick processing during Okazaki fragment maturation requires the coordinated action of DNA polymerase δ (Pol δ) and the FLAP endonuclease FEN1. Misregulation of this process leads to the accumu...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC528896/ https://ncbi.nlm.nih.gov/pubmed/15520275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1252304 |
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