Idling by DNA polymerase δ maintains a ligatable nick during lagging-strand DNA replication

During each yeast cell cycle, ∼100,000 nicks are generated during lagging-strand DNA replication. Efficient nick processing during Okazaki fragment maturation requires the coordinated action of DNA polymerase δ (Pol δ) and the FLAP endonuclease FEN1. Misregulation of this process leads to the accumu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Garg, Parie, Stith, Carrie M., Sabouri, Nasim, Johansson, Erik, Burgers, Peter M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2004
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC528896/
https://ncbi.nlm.nih.gov/pubmed/15520275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1252304
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge