Idling by DNA polymerase δ maintains a ligatable nick during lagging-strand DNA replication

During each yeast cell cycle, ∼100,000 nicks are generated during lagging-strand DNA replication. Efficient nick processing during Okazaki fragment maturation requires the coordinated action of DNA polymerase δ (Pol δ) and the FLAP endonuclease FEN1. Misregulation of this process leads to the accumu...

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Bibliografische Detailangaben

Veröffentlicht in:	Genes Dev
Hauptverfasser:	Garg, Parie, Stith, Carrie M., Sabouri, Nasim, Johansson, Erik, Burgers, Peter M.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Cold Spring Harbor Laboratory Press 2004
Schlagworte:	Research Papers
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC528896/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15520275/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1252304
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