Resolution of co-eluting isomers of anti-inflammatory drugs conjugated to carbonic anhydrase inhibitors from plasma in liquid chromatography by energy-resolved tandem mass spectrometry

Rheumatoid arthritis (RA) is a chronic inflammatory disease caused by a faulty autoimmune response. Recently, it was reported that some human carbonic anhydrases (CAs) isoforms are overexpressed in inflamed synovium of RA patients. New CA inhibitors (CAIs) incorporating CA-binding moiety and the cyc...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Menicatti, Marta, Pallecchi, Marco, Bua, Silvia, Vullo, Daniela, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla, Carta, Fabrizio, Supuran, Claudiu T., Bartolucci, Gianluca
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010112/
https://ncbi.nlm.nih.gov/pubmed/29536775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1445737
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