Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors

[Image: see text] A series of benzenesulfonamides bearing selenourea moieties was obtained considering the ureido-sulfonamide SLC-0111, in Phase I clinical trials as antitumor agent, as a lead molecule. All compounds showed interesting inhibition potencies against the physiologically relevant human...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Angeli, Andrea, Tanini, Damiano, Peat, Thomas S., Di Cesare Mannelli, Lorenzo, Bartolucci, Gianluca, Capperucci, Antonella, Ghelardini, Carla, Supuran, Claudiu T., Carta, Fabrizio
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601372/
https://ncbi.nlm.nih.gov/pubmed/28947945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00280
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