Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases

[Image: see text] Incorporation of the purine/pyrimidine moieties as tails to classical benzenesulfonamide scaffolds afforded two series of human (h) carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. The compounds were designed according to the molecular hybridization approach, in order to modulate th...

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Argitaratua izan da:ACS Med Chem Lett
Egile Nagusiak: Nocentini, Alessio, Bua, Silvia, Lomelino, Carrie L., McKenna, Robert, Menicatti, Marta, Bartolucci, Gianluca, Tenci, Barbara, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla, Gratteri, Paola, Supuran, Claudiu T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2017
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733260/
https://ncbi.nlm.nih.gov/pubmed/29259754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00399
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