Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases

[Image: see text] Incorporation of the purine/pyrimidine moieties as tails to classical benzenesulfonamide scaffolds afforded two series of human (h) carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. The compounds were designed according to the molecular hybridization approach, in order to modulate th...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Nocentini, Alessio, Bua, Silvia, Lomelino, Carrie L., McKenna, Robert, Menicatti, Marta, Bartolucci, Gianluca, Tenci, Barbara, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla, Gratteri, Paola, Supuran, Claudiu T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2017
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733260/
https://ncbi.nlm.nih.gov/pubmed/29259754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00399
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