Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action

[Image: see text] The “tail approach” has become a milestone in human carbonic anhydrase inhibitor (hCAI) design for various therapeutics, including antiglaucoma agents. Besides the classical hydrophobic/hydrophilic division of hCAs active site, several subpockets have been identified at the middle/...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Bonardi, Alessandro, Nocentini, Alessio, Bua, Silvia, Combs, Jacob, Lomelino, Carrie, Andring, Jacob, Lucarini, Laura, Sgambellone, Silvia, Masini, Emanuela, McKenna, Robert, Gratteri, Paola, Supuran, Claudiu T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8008423/
https://ncbi.nlm.nih.gov/pubmed/32519851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00733
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