The role of 5-arylalkylamino- and 5-piperazino- moieties on the 7-aminopyrazolo[4,3-d]pyrimidine core in affecting adenosine A(1) and A(2A) receptor affinity and selectivity profiles

New 7-amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives, substituted at the 5-position with aryl(alkyl)amino- and 4-substituted-piperazin-1-yl- moieties, were synthesized with the aim of targeting human (h) adenosine A(1) and/or A(2A) receptor subtypes. On the whole, the novel derivatives 1–24 sha...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Squarcialupi, Lucia, Betti, Marco, Catarzi, Daniela, Varano, Flavia, Falsini, Matteo, Ravani, Annalisa, Pasquini, Silvia, Vincenzi, Fabrizio, Salmaso, Veronica, Sturlese, Mattia, Varani, Katia, Moro, Stefano, Colotta, Vittoria
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009979/
https://ncbi.nlm.nih.gov/pubmed/28114825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2016.1247060
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