Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and IGF-1R

Novel 4-benzylamino benzo-anellated pyrrolo[2,3-b]pyridines have been synthesized with varied substitution patterns both at the molecular scaffold of the benzo-anellated ring and at the 4-benzylamino residue. With a structural similarity to substituted thieno[2,3-d]pyrimidines as epidermal growth fa...

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Bibliografiske detaljer
Udgivet i:J Enzyme Inhib Med Chem
Main Authors: Hempel, Cornelius, Totzke, Frank, Schächtele, Christoph, Najjar, Abdulkarim, Sippl, Wolfgang, Ritter, Christoph, Hilgeroth, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2017
Fag:
Short Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009933/
https://ncbi.nlm.nih.gov/pubmed/28097905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2016.1247062
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