Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and PDGFR-β related to anticancer drug resistance

With ongoing resistance problems against the marketed EGFR inhibitors having a quinazoline core scaffold there is a need for the development of novel inhibitors having a modified scaffold and, thus, expected lower EGFR resistance problems. An additional problem concerning EGFR inhibitor resistance i...

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Bibliographische Detailangaben
Veröffentlicht in:J Enzyme Inhib Med Chem
Hauptverfasser: Fischer, Tim, Najjar, Abdulkarim, Totzke, Frank, Schächtele, Christoph, Sippl, Wolfgang, Ritter, Christoph, Hilgeroth, Andreas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
Schlagworte:
Short Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009873/
https://ncbi.nlm.nih.gov/pubmed/29098884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1370583
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