Introduction of pyrrolidineoxy or piperidineamino group at the 4-position of quinazoline leading to novel quinazoline-based phosphoinositide 3-kinase delta (PI3Kδ) inhibitors

Phosphoinositide 3-kinase Delta (PI3Kδ) plays a key role in B-cell signal transduction and inhibition of PI3Kδ was confirmed to have clinical benefit in certain types of activation of B-cell malignancies. Herein, we reported a novel series of 4-pyrrolidineoxy or 4-piperidineamino substituted quinazo...

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Detaylı Bibliyografya
Yayımlandı:J Enzyme Inhib Med Chem
Asıl Yazarlar: Xin, Minhang, Duan, Weiming, Feng, Yifan, Hei, Yuan-Yuan, Zhang, Hao, Shen, Ying, Zhao, Hong-Yi, Mao, Shuai, Zhang, San-Qi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Taylor & Francis 2018
Konular:
Short Communication
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009876/
https://ncbi.nlm.nih.gov/pubmed/29536777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1444608
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