Phosphoinositide 3-Kinase (PI3K) Subunit p110δ Is Essential for Trophoblast Cell Differentiation and Placental Development in Mouse

Maternal PI3K p110δ has been implicated in smaller litter sizes in mice, but its underlying mechanism remains unclear. The placenta is an indispensable chimeric organ that supports mammalian embryonic development. Using a mouse model of genetic inactivation of PI3K p110δ (p110δ(D910A/D910A)), we sho...

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Опубликовано в: :Sci Rep
Главные авторы: Hu, Xiwen, Li, Jiangchao, Zhang, Qianqian, Zheng, Lingyun, Wang, Guang, Zhang, Xiaohan, Zhang, Jingli, Gu, Quliang, Ye, Yuxiang, Guo, Sun-Wei, Yang, Xuesong, Wang, Lijing
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910077/
https://ncbi.nlm.nih.gov/pubmed/27306493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28201
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