Phosphoinositide 3-Kinase (PI3K) Subunit p110δ Is Essential for Trophoblast Cell Differentiation and Placental Development in Mouse

Maternal PI3K p110δ has been implicated in smaller litter sizes in mice, but its underlying mechanism remains unclear. The placenta is an indispensable chimeric organ that supports mammalian embryonic development. Using a mouse model of genetic inactivation of PI3K p110δ (p110δ(D910A/D910A)), we sho...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Hu, Xiwen, Li, Jiangchao, Zhang, Qianqian, Zheng, Lingyun, Wang, Guang, Zhang, Xiaohan, Zhang, Jingli, Gu, Quliang, Ye, Yuxiang, Guo, Sun-Wei, Yang, Xuesong, Wang, Lijing
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910077/
https://ncbi.nlm.nih.gov/pubmed/27306493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28201
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