Essential, Nonredundant Role for the Phosphoinositide 3-Kinase p110δ in Signaling by the B-Cell Receptor Complex

Many receptor and nonreceptor tyrosine kinases activate phosphoinositide 3-kinases (PI3Ks). To assess the role of the δ isoform of the p110 catalytic subunit of PI3Ks, we derived enzyme-deficient mice. The mice are viable but have decreased numbers of mature B cells, a block in pro-B-cell differenti...

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Detalhes bibliográficos
Main Authors: Jou, Shiann-Tarng, Carpino, Nick, Takahashi, Yutaka, Piekorz, Roland, Chao, Jyh-Rong, Carpino, Neena, Wang, Demin, Ihle, James N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC139888/
https://ncbi.nlm.nih.gov/pubmed/12446777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.24.8580-8591.2002
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