Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.

We have reported previously that Ras interacts with the catalytic subunit of phosphoinositide 3-kinase (PI 3-kinase) in a GTP-dependent manner. The affinity of the interaction of Ras-GTP with p85alpha/p110alpha is shown here to be approximately 150 nM. The site of interaction on the p110alpha and be...

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Veröffentlicht in:EMBO J
Hauptverfasser: Rodriguez-Viciana, P, Warne, P H, Vanhaesebroeck, B, Waterfield, M D, Downward, J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1996
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC450176/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8665852/
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