Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation

Eight human isoforms of phosphoinositide 3-kinases (PI3Ks) exist, but their individual functions remain poorly understood. Here, we show that different human small cell lung carcinoma (SCLC) cell lines overexpress distinct subsets of class I(A) and II PI3Ks, which results in striking differences in...

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Detalhes bibliográficos
Main Authors: Arcaro, Alexandre, Khanzada, Umme K., Vanhaesebroeck, Bart, Tetley, Teresa D., Waterfield, Michael D., Seckl, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2002
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC129034/
https://ncbi.nlm.nih.gov/pubmed/12356726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf512
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