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Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation

Eight human isoforms of phosphoinositide 3-kinases (PI3Ks) exist, but their individual functions remain poorly understood. Here, we show that different human small cell lung carcinoma (SCLC) cell lines overexpress distinct subsets of class I(A) and II PI3Ks, which results in striking differences in...

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Autors principals: Arcaro, Alexandre, Khanzada, Umme K., Vanhaesebroeck, Bart, Tetley, Teresa D., Waterfield, Michael D., Seckl, Michael J.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC129034/
https://ncbi.nlm.nih.gov/pubmed/12356726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf512
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