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Role of conformational dynamics in the evolution of novel enzyme function
The free energy landscape concept that describes enzymes as an ensemble of differently populated conformational sub-states in dynamic equilibrium is key for evaluating enzyme activity, enantioselectivity, and specificity. Mutations introduced in the enzyme sequence can alter the populations of the p...
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| Опубликовано в: : | Chem Commun (Camb) |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Royal Society of Chemistry
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6009289/ https://ncbi.nlm.nih.gov/pubmed/29780987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc02426j |
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