Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2

The polyadenosine-diphosphate-ribose polymerase 14 (PARP14) has been implicated in DNA damage response pathways for homologous recombination. PARP14 contains three (ADP ribose binding) macrodomains (MD) whose exact contribution to overall PARP14 function in pathology remains unclear. A medium throug...

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Publicado no:Bioorg Med Chem
Main Authors: Moustakim, Moses, Riedel, Kerstin, Schuller, Marion, Gehring, Andrè P., Monteiro, Octovia P., Martin, Sarah P., Fedorov, Oleg, Heer, Jag, Dixon, Darren J., Elkins, Jonathan M., Knapp, Stefan, Bracher, Franz, Brennan, Paul E.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008491/
https://ncbi.nlm.nih.gov/pubmed/29567296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.03.020
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