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Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila
Mutations in the genes for PINK1 and parkin cause Parkinson’s disease. PINK1 and parkin cooperate in the selective autophagic degradation of damaged mitochondria (mitophagy) in cultured cells. However, evidence for their role in mitophagy in vivo is still scarce. Here, we generated a Drosophila mode...
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| Опубликовано в: : | eLife |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
eLife Sciences Publications, Ltd
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6008047/ https://ncbi.nlm.nih.gov/pubmed/29809156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35878 |
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