Mass spectrometric measurement of urinary kynurenine-to-tryptophan ratio in children with and without urinary tract infection

BACKGROUND: Indoleamine-2,3-dioxygenase (IDO) catalyzes the first step of tryptophan (Trp) catabolism, yielding kynurenine (Kyn) metabolites. The kynurenine-to-tryptophan (K/T) ratio is used as a surrogate for biological IDO enzyme activity. IDO expression is increased during Escherichia coli urinar...

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Publicat a:Clin Biochem
Autors principals: Yarbrough, Melanie L., Briden, Kelleigh E., Mitsios, John V., Weindel, Annette L., Terrill, Cindy M., Hunstad, David A., Dietzen, Dennis J.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007864/
https://ncbi.nlm.nih.gov/pubmed/29679555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clinbiochem.2018.04.014
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