Human β-Defensin-1 and β-Defensin-3 (Mouse Ortholog mBD14) Function as Full Endogenous Agonists at Select Melanocortin Receptors

β-Defensin 3 (BD3) was identified as a ligand for the melanocortin receptors (MCRs) in 2007, although the pharmacology activity of BD3 has not been clearly elucidated. Herein, it is demonstrated that human and mouse BD3 are full micromolar agonists at the MCRs. Furthermore, mouse and human β-defensi...

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Publicado no:J Med Chem
Main Authors: Ericson, Mark D., Singh, Anamika, Tala, Srinivasa R., Haslach, Erica M., Dirain, Marvin L. S., Schaub, Jay W., Flores, Viktor, Eick, Natalie, Lensing, Cody J., Freeman, Katie T., Smeester, Branden A., Adank, Danielle N, Wilber, Stacey L., Speth, Robert, Haskell-Luevano, Carrie
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007841/
https://ncbi.nlm.nih.gov/pubmed/29578343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00251
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