An ATP-Dependent Ligase with Substrate Flexibility Involved in Assembly of the Peptidyl Nucleoside Antibiotic Polyoxin

Polyoxin (POL) is an unusual peptidyl nucleoside antibiotic, in which the peptidyl moiety and nucleoside skeleton are linked by an amide bond. However, their biosynthesis remains poorly understood. Here, we report the deciphering of PolG as an ATP-dependent ligase responsible for the assembly of POL...

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Bibliografski detalji
Izdano u:Appl Environ Microbiol
Glavni autori: Gong, Rong, Qi, Jianzhao, Wu, Pan, Cai, You-Sheng, Ma, Hongmin, Liu, Yang, Duan, He, Wang, Meng, Deng, Zixin, Price, Neil P. J., Chen, Wenqing
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2018
Teme:
Enzymology and Protein Engineering
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007123/
https://ncbi.nlm.nih.gov/pubmed/29703734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00501-18
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