An ATP-Dependent Ligase with Substrate Flexibility Involved in Assembly of the Peptidyl Nucleoside Antibiotic Polyoxin

Polyoxin (POL) is an unusual peptidyl nucleoside antibiotic, in which the peptidyl moiety and nucleoside skeleton are linked by an amide bond. However, their biosynthesis remains poorly understood. Here, we report the deciphering of PolG as an ATP-dependent ligase responsible for the assembly of POL...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Appl Environ Microbiol
Prif Awduron: Gong, Rong, Qi, Jianzhao, Wu, Pan, Cai, You-Sheng, Ma, Hongmin, Liu, Yang, Duan, He, Wang, Meng, Deng, Zixin, Price, Neil P. J., Chen, Wenqing
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2018
Pynciau:
Enzymology and Protein Engineering
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007123/
https://ncbi.nlm.nih.gov/pubmed/29703734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00501-18
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