An ATP-Dependent Ligase with Substrate Flexibility Involved in Assembly of the Peptidyl Nucleoside Antibiotic Polyoxin

Polyoxin (POL) is an unusual peptidyl nucleoside antibiotic, in which the peptidyl moiety and nucleoside skeleton are linked by an amide bond. However, their biosynthesis remains poorly understood. Here, we report the deciphering of PolG as an ATP-dependent ligase responsible for the assembly of POL...

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Detalhes bibliográficos
Publicado no:Appl Environ Microbiol
Main Authors: Gong, Rong, Qi, Jianzhao, Wu, Pan, Cai, You-Sheng, Ma, Hongmin, Liu, Yang, Duan, He, Wang, Meng, Deng, Zixin, Price, Neil P. J., Chen, Wenqing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Enzymology and Protein Engineering
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007123/
https://ncbi.nlm.nih.gov/pubmed/29703734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00501-18
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