An ATP-Dependent Ligase with Substrate Flexibility Involved in Assembly of the Peptidyl Nucleoside Antibiotic Polyoxin

Polyoxin (POL) is an unusual peptidyl nucleoside antibiotic, in which the peptidyl moiety and nucleoside skeleton are linked by an amide bond. However, their biosynthesis remains poorly understood. Here, we report the deciphering of PolG as an ATP-dependent ligase responsible for the assembly of POL...

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Bibliografiske detaljer
Udgivet i:Appl Environ Microbiol
Main Authors: Gong, Rong, Qi, Jianzhao, Wu, Pan, Cai, You-Sheng, Ma, Hongmin, Liu, Yang, Duan, He, Wang, Meng, Deng, Zixin, Price, Neil P. J., Chen, Wenqing
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2018
Fag:
Enzymology and Protein Engineering
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007123/
https://ncbi.nlm.nih.gov/pubmed/29703734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00501-18
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