An ATP-Dependent Ligase with Substrate Flexibility Involved in Assembly of the Peptidyl Nucleoside Antibiotic Polyoxin

Polyoxin (POL) is an unusual peptidyl nucleoside antibiotic, in which the peptidyl moiety and nucleoside skeleton are linked by an amide bond. However, their biosynthesis remains poorly understood. Here, we report the deciphering of PolG as an ATP-dependent ligase responsible for the assembly of POL...

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Dettagli Bibliografici
Pubblicato in:Appl Environ Microbiol
Autori principali: Gong, Rong, Qi, Jianzhao, Wu, Pan, Cai, You-Sheng, Ma, Hongmin, Liu, Yang, Duan, He, Wang, Meng, Deng, Zixin, Price, Neil P. J., Chen, Wenqing
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2018
Soggetti:
Enzymology and Protein Engineering
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007123/
https://ncbi.nlm.nih.gov/pubmed/29703734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00501-18
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