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Stapling of unprotected helical peptides via photo-induced intramolecular thiol–yne hydrothiolation

Peptide stapling emerged as a versatile strategy to recapitulate the bioactive helical conformation of unstructured short peptides in water to improve their therapeutic properties in targeting intracellular “undruggable” targets. Here, we describe the development of photo-induced intramolecular thio...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Chem Sci
Main Authors: Tian, Yuan, Li, Jingxu, Zhao, Hui, Zeng, Xiangze, Wang, Dongyuan, Liu, Qisong, Niu, Xiaogang, Huang, Xuhui, Xu, Naihan, Li, Zigang
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006495/
https://ncbi.nlm.nih.gov/pubmed/29997825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc00106h
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