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Stapling of unprotected helical peptides via photo-induced intramolecular thiol–yne hydrothiolation
Peptide stapling emerged as a versatile strategy to recapitulate the bioactive helical conformation of unstructured short peptides in water to improve their therapeutic properties in targeting intracellular “undruggable” targets. Here, we describe the development of photo-induced intramolecular thio...
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| Publicado no: | Chem Sci |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6006495/ https://ncbi.nlm.nih.gov/pubmed/29997825 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc00106h |
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