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Asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine

Rhodium-catalyzed highly regio- and enantioselective hydroamination of allenes is reported. Exclusive branched selectivities and excellent enantioselectivities were achieved applying a rhodium(i)/Josiphos catalyst. This method permits the practical synthesis of valuable α-chiral allylic amines using...

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Publié dans:Chem Sci
Auteurs principaux: Xu, Kun, Wang, Yu-Hsuan, Khakyzadeh, Vahid, Breit, Bernhard
Format: Artigo
Langue:Inglês
Publié: Royal Society of Chemistry 2016
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006468/
https://ncbi.nlm.nih.gov/pubmed/29997823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc04984a
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