Inducing CCR5Δ32/Δ32 Homozygotes in the Human Jurkat CD4+ Cell Line and Primary CD4+ Cells by CRISPR-Cas9 Genome-Editing Technology

C-C chemokine receptor type 5 (CCR5) is the main co-receptor for HIV entry into the target CD4+ cells, and homozygous CCR5Δ32/Δ32 cells are resistant to CCR5-tropic HIV infection. However, the CCR5Δ32/Δ32 homozygous donors in populations are rare. Here we developed a simple approach to induce CCR5Δ3...

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Veröffentlicht in:Mol Ther Nucleic Acids
Hauptverfasser: Qi, Chunxia, Li, Dan, Jiang, Xiangxiang, Jia, Xiaopeng, Lu, Lingling, Wang, Yanfeng, Sun, Jinhuan, Shao, Yiming, Wei, Min
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005807/
https://ncbi.nlm.nih.gov/pubmed/30195765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.05.012
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