Incorporation of GSTA1 genetic variations into a population pharmacokinetic model for IV busulfan in paediatric hematopoietic stem cell transplantation

AIMS: The aim of this study is to develop a population pharmacokinetic (PopPK) model for intravenous busulfan in children that incorporates variants of GSTA1, gene coding for the main enzyme in busulfan metabolism. METHODS: Busulfan concentration–time data was collected from 112 children and adolesc...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Nava, Tiago, Kassir, Nastya, Rezgui, Mohamed Aziz, Uppugunduri, Chakradhara Rao Satyanarayana, Huezo‐Diaz Curtis, Patricia, Duval, Michel, Théoret, Yves, Daudt, Liane E., Litalien, Catherine, Ansari, Marc, Krajinovic, Maja, Bittencourt, Henrique
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005620/
https://ncbi.nlm.nih.gov/pubmed/29469189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13566
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