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p62/sequestosome 1 deficiency accelerates osteoclastogenesis in vitro and leads to Paget's disease–like bone phenotypes in mice
The sequestosome 1 gene encodes the p62 protein and is the major genetic risk factor associated with Paget's disease of bone. In 2004, p62 was reported to up-regulate osteoclast differentiation by activating the transcription factors Nfatc1 and NF-κB. Here, we characterized the osteoclastogenic...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6005453/ https://ncbi.nlm.nih.gov/pubmed/29555685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002449 |
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