Smad4 deficiency impairs chondrocyte hypertrophy via the Runx2 transcription factor in mouse skeletal development

Chondrocyte hypertrophy is the terminal step in chondrocyte differentiation and is crucial for endochondral bone formation. How signaling pathways regulate chondrocyte hypertrophic differentiation remains incompletely understood. In this study, using a Tbx18:Cre (Tbx18(Cre/+)) gene-deletion approach...

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Vydáno v:J Biol Chem
Hlavní autoři: Yan, Jianyun, Li, Jun, Hu, Jun, Zhang, Lu, Wei, Chengguo, Sultana, Nishat, Cai, Xiaoqiang, Zhang, Weijia, Cai, Chen-Leng
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Developmental Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005452/
https://ncbi.nlm.nih.gov/pubmed/29735531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001825
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