Randomized phase III and extension studies: efficacy and impacts on quality of life of naldemedine in subjects with opioid-induced constipation and cancer

BACKGROUND: The efficacy and safety of naldemedine (a peripherally acting µ-opioid receptor antagonist) for opioid-induced constipation (OIC) in subjects with cancer was demonstrated in the primary report of a phase III, double-blind study (COMPOSE-4) and its open-label extension (COMPOSE-5). The pr...

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Detalles Bibliográficos
Publicado en:Ann Oncol
Main Authors: Katakami, N, Harada, T, Murata, T, Shinozaki, K, Tsutsumi, M, Yokota, T, Arai, M, Tada, Y, Narabayashi, M, Boku, N
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005145/
https://ncbi.nlm.nih.gov/pubmed/32151367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdy118
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