Noonan syndrome-causing SHP2 mutants impair ERK-dependent chondrocyte differentiation during endochondral bone growth

Growth retardation is a constant feature of Noonan syndrome (NS) but its physiopathology remains poorly understood. We previously reported that hyperactive NS-causing SHP2 mutants impair the systemic production of insulin‐like growth factor 1 (IGF1) through hyperactivation of the RAS/extracellular s...

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Udgivet i:Hum Mol Genet
Main Authors: Tajan, Mylène, Pernin-Grandjean, Julie, Beton, Nicolas, Gennero, Isabelle, Capilla, Florence, Neel, Benjamin G, Araki, Toshiyuki, Valet, Philippe, Tauber, Maithé, Salles, Jean-Pierre, Yart, Armelle, Edouard, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005060/
https://ncbi.nlm.nih.gov/pubmed/29659837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy133
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