Functional Effects of PTPN11 (SHP2) Mutations Causing LEOPARD Syndrome on Epidermal Growth Factor-Induced Phosphoinositide 3-Kinase/AKT/Glycogen Synthase Kinase 3β Signaling

LEOPARD syndrome (LS), a disorder with multiple developmental abnormalities, is mainly due to mutations that impair the activity of the tyrosine phosphatase SHP2 (PTPN11). How these alterations cause the disease remains unknown. We report here that fibroblasts isolated from LS patients displayed str...

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Αποθηκεύτηκε σε:
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Κύριοι συγγραφείς: Edouard, Thomas, Combier, Jean-Philippe, Nédélec, Audrey, Bel-Vialar, Sophie, Métrich, Mélanie, Conte-Auriol, Francoise, Lyonnet, Stanislas, Parfait, Béatrice, Tauber, Maithé, Salles, Jean-Pierre, Lezoualc'h, Frank, Yart, Armelle, Raynal, Patrick
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology (ASM) 2010
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Articles
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863708/
https://ncbi.nlm.nih.gov/pubmed/20308328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00646-09
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