Change of Amyloid-β 1-42 Toxic Conformer Ratio After Cerebrospinal Fluid Diversion Predicts Long-Term Cognitive Outcome in Patients with Idiopathic Normal Pressure Hydrocephalus

BACKGROUND: Alzheimer’s disease (AD) pathology in idiopathic normal pressure hydrocephalus (iNPH) contributes to poor shunt responses. Amyloid-β 1– 42 (Aβ(42)) toxic conformer was recently identified with features of rapid oligomerization, strong neurotoxicity and synaptotoxicity. OBJECTIVE: This ob...

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Detalhes bibliográficos
Publicado no:J Alzheimers Dis
Main Authors: Akiba, Chihiro, Nakajima, Madoka, Miyajima, Masakazu, Ogino, Ikuko, Motoi, Yumiko, Kawamura, Kaito, Adachi, Satoshi, Kondo, Akihide, Sugano, Hidenori, Tokuda, Takahiko, Irie, Kazuhiro, Arai, Hajime
Formato: Artigo
Idioma:Inglês
Publicado em: IOS Press 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004932/
https://ncbi.nlm.nih.gov/pubmed/29710721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-180059
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