Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-dependent SMAC Mediated Apoptotic Response in Non-Small Cell Lung Cancer

PURPOSE: The retinoblastoma tumor suppressor (RB), a key regulator of cell cycle progression and proliferation, is functionally suppressed in up to 50% of non-small cell lung cancer (NSCLC). RB function is exquisitely controlled by a series of proteins including the CyclinD-CDK4/6 complex. In the cu...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Clin Cancer Res
Hoofdauteurs: Thangavel, Chellappagounder, Boopathi, Ettickan, Liu, Yi, McNair, Christopher, Haber, Alex, Perepelyuk, Maryna, Bhardwaj, Anshul, Addya, Sankar, Ertel, Adam, Shoyele, Sunday, Birbe, Ruth, Salvino, Joseph M, Dicker, Adam P, Knudsen, Karen E, Den., Robert B
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004790/
https://ncbi.nlm.nih.gov/pubmed/29311118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2074
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items