Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-dependent SMAC Mediated Apoptotic Response in Non-Small Cell Lung Cancer

PURPOSE: The retinoblastoma tumor suppressor (RB), a key regulator of cell cycle progression and proliferation, is functionally suppressed in up to 50% of non-small cell lung cancer (NSCLC). RB function is exquisitely controlled by a series of proteins including the CyclinD-CDK4/6 complex. In the cu...

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Pubblicato in:Clin Cancer Res
Autori principali: Thangavel, Chellappagounder, Boopathi, Ettickan, Liu, Yi, McNair, Christopher, Haber, Alex, Perepelyuk, Maryna, Bhardwaj, Anshul, Addya, Sankar, Ertel, Adam, Shoyele, Sunday, Birbe, Ruth, Salvino, Joseph M, Dicker, Adam P, Knudsen, Karen E, Den., Robert B
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004790/
https://ncbi.nlm.nih.gov/pubmed/29311118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2074
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