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Gravin regulates centrosome function through PLK1

We propose to understand how the mitotic kinase PLK1 drives chromosome segregation errors, with a specific focus on Gravin, a PLK1 scaffold. In both three-dimensional primary prostate cancer cell cultures that are prone to Gravin depletion and Gravin short hairpin RNA (shRNA)–treated cells, an incre...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Mol Biol Cell
Hauptverfasser: Colicino, Erica G., Garrastegui, Alice M., Freshour, Judy, Santra, Peu, Post, Dawn E., Kotula, Leszek, Hehnly, Heidi
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004580/
https://ncbi.nlm.nih.gov/pubmed/29282278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-08-0524
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