Selection of Plasmodium falciparum cytochrome B mutants by putative PfNDH2 inhibitors

Malaria control is threatened by a limited pipeline of effective pharmaceuticals against drug-resistant strains of Plasmodium falciparum. Components of the mitochondrial electron transport chain (ETC) are attractive targets for drug development, owing to exploitable differences between the parasite...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Lane, Kristin D., Mu, Jianbing, Lu, Jinghua, Windle, Sean T., Liu, Anna, Sun, Peter D., Wellems, Thomas E.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004454/
https://ncbi.nlm.nih.gov/pubmed/29844160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1804492115
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