Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)

[Image: see text] Following a program undertaken to identify hit compounds against NADH:ubiquinone oxidoreductase (PfNDH2), a novel enzyme target within the malaria parasite Plasmodium falciparum, hit to lead optimization led to identification of CK-2-68, a molecule suitable for further development....

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Main Authors: Leung, Suet C., Gibbons, Peter, Amewu, Richard, Nixon, Gemma L., Pidathala, Chandrakala, Hong, W. David, Pacorel, Bénédicte, Berry, Neil G., Sharma, Raman, Stocks, Paul A., Srivastava, Abhishek, Shone, Alison E., Charoensutthivarakul, Sitthivut, Taylor, Lee, Berger, Olivier, Mbekeani, Alison, Hill, Alasdair, Fisher, Nicholas E., Warman, Ashley J., Biagini, Giancarlo A., Ward, Stephen A., O’Neill, Paul M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351724/
https://ncbi.nlm.nih.gov/pubmed/22364417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201184h
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