The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cancer cells

Cancer cells are reprogrammed to consume large amounts of glucose to support anabolic biosynthetic pathways. However, blood perfusion and consequently the supply with glucose are frequently inadequate in solid cancers. PEPCK-M (PCK2), the mitochondrial isoform of phosphoenolpyruvate carboxykinase (P...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Leithner, Katharina, Triebl, Alexander, Trötzmüller, Martin, Hinteregger, Barbara, Leko, Petra, Wieser, Beatrix I., Grasmann, Gabriele, Bertsch, Alexandra L., Züllig, Thomas, Stacher, Elvira, Valli, Alessandro, Prassl, Ruth, Olschewski, Andrea, Harris, Adrian L., Köfeler, Harald C., Olschewski, Horst, Hrzenjak, Andelko
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004450/
https://ncbi.nlm.nih.gov/pubmed/29844165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719871115
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