The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cancer cells

Cancer cells are reprogrammed to consume large amounts of glucose to support anabolic biosynthetic pathways. However, blood perfusion and consequently the supply with glucose are frequently inadequate in solid cancers. PEPCK-M (PCK2), the mitochondrial isoform of phosphoenolpyruvate carboxykinase (P...

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Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Leithner, Katharina, Triebl, Alexander, Trötzmüller, Martin, Hinteregger, Barbara, Leko, Petra, Wieser, Beatrix I., Grasmann, Gabriele, Bertsch, Alexandra L., Züllig, Thomas, Stacher, Elvira, Valli, Alessandro, Prassl, Ruth, Olschewski, Andrea, Harris, Adrian L., Köfeler, Harald C., Olschewski, Horst, Hrzenjak, Andelko
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2018
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004450/
https://ncbi.nlm.nih.gov/pubmed/29844165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719871115
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