The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cancer cells

Cancer cells are reprogrammed to consume large amounts of glucose to support anabolic biosynthetic pathways. However, blood perfusion and consequently the supply with glucose are frequently inadequate in solid cancers. PEPCK-M (PCK2), the mitochondrial isoform of phosphoenolpyruvate carboxykinase (P...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Leithner, Katharina, Triebl, Alexander, Trötzmüller, Martin, Hinteregger, Barbara, Leko, Petra, Wieser, Beatrix I., Grasmann, Gabriele, Bertsch, Alexandra L., Züllig, Thomas, Stacher, Elvira, Valli, Alessandro, Prassl, Ruth, Olschewski, Andrea, Harris, Adrian L., Köfeler, Harald C., Olschewski, Horst, Hrzenjak, Andelko
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004450/
https://ncbi.nlm.nih.gov/pubmed/29844165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719871115
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