The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cancer cells

Cancer cells are reprogrammed to consume large amounts of glucose to support anabolic biosynthetic pathways. However, blood perfusion and consequently the supply with glucose are frequently inadequate in solid cancers. PEPCK-M (PCK2), the mitochondrial isoform of phosphoenolpyruvate carboxykinase (P...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Leithner, Katharina, Triebl, Alexander, Trötzmüller, Martin, Hinteregger, Barbara, Leko, Petra, Wieser, Beatrix I., Grasmann, Gabriele, Bertsch, Alexandra L., Züllig, Thomas, Stacher, Elvira, Valli, Alessandro, Prassl, Ruth, Olschewski, Andrea, Harris, Adrian L., Köfeler, Harald C., Olschewski, Horst, Hrzenjak, Andelko
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004450/
https://ncbi.nlm.nih.gov/pubmed/29844165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719871115
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