Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1

T cell-engaging bispecific antibodies (biAbs) present a promising strategy for cancer immunotherapy, and numerous bispecific formats have been developed for retargeting cytolytic T cells toward tumor cells. To explore the therapeutic utility of T cell-engaging biAbs targeting the receptor tyrosine k...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Qi, Junpeng, Li, Xiuling, Peng, Haiyong, Cook, Erika M., Dadashian, Eman L., Wiestner, Adrian, Park, HaJeung, Rader, Christoph
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2018
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004433/
https://ncbi.nlm.nih.gov/pubmed/29844189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719905115
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