Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1

T cell-engaging bispecific antibodies (biAbs) present a promising strategy for cancer immunotherapy, and numerous bispecific formats have been developed for retargeting cytolytic T cells toward tumor cells. To explore the therapeutic utility of T cell-engaging biAbs targeting the receptor tyrosine k...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Qi, Junpeng, Li, Xiuling, Peng, Haiyong, Cook, Erika M., Dadashian, Eman L., Wiestner, Adrian, Park, HaJeung, Rader, Christoph
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2018
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004433/
https://ncbi.nlm.nih.gov/pubmed/29844189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719905115
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