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Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein processing

The processing of amyloid precursor protein (APP) to the neurotoxic pro-aggregatory Aβ peptide is controlled by the mechanisms that govern the trafficking and localisation of APP. We hypothesised that genes involved in endosomal protein sorting could play an important role in regulating APP processi...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Mol Life Sci
Hauptverfasser: Mukadam, Aamir S., Breusegem, Sophia Y., Seaman, Matthew N. J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003983/
https://ncbi.nlm.nih.gov/pubmed/29368044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-018-2752-9
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