PI3P regulates sorting and processing of amyloid precursor protein through the endosomal system

Defects in endosomal sorting have been implicated in Alzheimer’s disease (AD). Endosomal traffic is largely controlled by phosphatidylinositol-3-phosphate (PI3P), a phosphoinositide synthesized primarily by lipid kinase Vps34. Here we show that PI3P is selectively deficient in brain tissue from huma...

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Détails bibliographiques
Auteurs principaux: Morel, Etienne, Chamoun, Zeina, Lasiecka, Zofia M., Chan, Robin B., Williamson, Rebecca L., Vetanovetz, Christopher, Dall’Armi, Claudia, Simoes, Sabrina, Point Du Jour, Kimberly S., McCabe, Brian D., Small, Scott A., Di Paolo, Gilbert
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905799/
https://ncbi.nlm.nih.gov/pubmed/23907271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3250
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