PI3P regulates sorting and processing of amyloid precursor protein through the endosomal system

Defects in endosomal sorting have been implicated in Alzheimer’s disease (AD). Endosomal traffic is largely controlled by phosphatidylinositol-3-phosphate (PI3P), a phosphoinositide synthesized primarily by lipid kinase Vps34. Here we show that PI3P is selectively deficient in brain tissue from huma...

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書誌詳細
主要な著者: Morel, Etienne, Chamoun, Zeina, Lasiecka, Zofia M., Chan, Robin B., Williamson, Rebecca L., Vetanovetz, Christopher, Dall’Armi, Claudia, Simoes, Sabrina, Point Du Jour, Kimberly S., McCabe, Brian D., Small, Scott A., Di Paolo, Gilbert
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905799/
https://ncbi.nlm.nih.gov/pubmed/23907271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3250
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