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PI3P regulates sorting and processing of amyloid precursor protein through the endosomal system
Defects in endosomal sorting have been implicated in Alzheimer’s disease (AD). Endosomal traffic is largely controlled by phosphatidylinositol-3-phosphate (PI3P), a phosphoinositide synthesized primarily by lipid kinase Vps34. Here we show that PI3P is selectively deficient in brain tissue from huma...
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| 主要な著者: | , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3905799/ https://ncbi.nlm.nih.gov/pubmed/23907271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3250 |
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