Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis

Rutaecarpine (RUT), evodiamine (EOD), and dehydroevodiamine (DHED) are the three main bioactive indoloquinazoline alkaloids isolated from Euodia rutaecarpa, a widely prescribed traditional Chinese medicine. Here, the structure-activity relationships of these analogs for aryl hydrocarbon receptor (AH...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Zhang, Youbo, Yan, Tingting, Sun, Dongxue, Xie, Cen, Zheng, Yiran, Zhang, Lei, Yagai, Tomoki, Krausz, Kristopher W., Bisson, William H., Yang, Xiuwei, Gonzalez, Frank J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003592/
https://ncbi.nlm.nih.gov/pubmed/29691238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.117.080176
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