Cisplatin-DNA adduct repair of transcribed genes is controlled by two circadian programs in mouse tissues

Cisplatin is a major cancer chemotherapeutic drug. It kills cancer cells by damaging their DNA, mainly in the form of Pt-d(GpG) diadducts. However, it also has serious side effects, including nephrotoxicity and hepatotoxicity that limit its usefulness. Chronotherapy is taking circadian time into acc...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Yang, Yanyan, Adebali, Ogun, Wu, Gang, Selby, Christopher P., Chiou, Yi-Ying, Rashid, Naim, Hu, Jinchuan, Hogenesch, John B., Sancar, Aziz
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003508/
https://ncbi.nlm.nih.gov/pubmed/29735688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1804493115
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