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Cisplatin-DNA adduct repair of transcribed genes is controlled by two circadian programs in mouse tissues
Cisplatin is a major cancer chemotherapeutic drug. It kills cancer cells by damaging their DNA, mainly in the form of Pt-d(GpG) diadducts. However, it also has serious side effects, including nephrotoxicity and hepatotoxicity that limit its usefulness. Chronotherapy is taking circadian time into acc...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6003508/ https://ncbi.nlm.nih.gov/pubmed/29735688 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1804493115 |
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