Copper-Catalyzed Chan–Lam Cyclopropylation of Phenols and Azaheterocycles

Small molecules containing cyclopropane–heteroatom linkages are commonly needed in medicinal chemistry campaigns, yet are problematic to prepare using existing methods. To address this issue, a scalable Chan–Lam cyclopropylation reaction using potassium cyclopropyl trifluoroborate has been developed...

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Bibliografiske detaljer
Udgivet i:J Org Chem
Main Authors: Derosa, Joseph, O’Duill, Miriam, Holcomb, Matthew, Boulous, Mark N., Patman, Ryan L., Wang, Fen, Tran-Dubé, Michelle, McAlpine, Indrawan, Engle, Keary M.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003411/
https://ncbi.nlm.nih.gov/pubmed/29498847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.7b03100
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